Philippe J V
Am J Obstet Gynecol. 1975 Dec 1;123(7):714-8. doi: 10.1016/0002-9378(75)90493-7.
The effects of preconceptional irradiation on female fertility were investigated in six groups of 35 nulliparous Swiss-Webster mice whole-body irradiated with single doses of 25, 50, 75, 100, 150, and 300 rads of 60Co. They were mated with nontreated males and killed on gestational day 18. The litters were recorded in the chronologic order of their occurrence within each group. The percentage of pregnancies decreased with the dose, while the prenatal loss increased. Up to 100 rads, the middle group of pregnancies was devoid of resorptions, fetal death, and congenital anomalies, thus giving rise to a "maximum viability enclave." Beyond this level those three adverse effects were more or less homogeneously distributed over the whole period for which pregnancies were recorded. Exencephaly, microcephaly, and eye defects were the most frequent malformations. Among other sequelae, hypertrophy of the higher pole occurred in the left kidney in the surviving infertile females killed 5 months after treatment.
研究了用单剂量25、50、75、100、150和300拉德的60Co对六组35只未生育的瑞士韦伯斯特雌性小鼠进行孕前全身照射的效果。它们与未处理的雄性小鼠交配，并在妊娠第18天处死。记录每组中按出生先后顺序排列的窝仔数。妊娠百分比随剂量增加而降低，而产前损失增加。在100拉德以下，中间组的妊娠没有吸收、胎儿死亡和先天性异常，从而形成了一个“最大活力区域”。超过这个水平，这三种不良影响在记录到的整个妊娠期间或多或少均匀分布。无脑畸形、小头畸形和眼部缺陷是最常见的畸形。在其他后遗症中，治疗后5个月处死的存活不育雌性小鼠的左肾出现上极肥大。
