Robinson Harriet L
Vaccine Research Center, Emory University, Atlanta, Georgia 30329, USA.
Nat Rev Immunol. 2002 Apr;2(4):239-50. doi: 10.1038/nri776.
The twenty-first century has begun with considerable success for new AIDS vaccines in macaque models. A common feature of these vaccines is their ability to induce high-frequency CD8+ T-cell responses that control, rather than prevent, infection with HIV. The new vaccines, which include DNA vaccines and live viral vectors, are based on technologies that have been developed since the start of the AIDS epidemic. The ultimate promise of these vaccines will be realized only when efficacy trials in humans are conducted.
在猕猴模型中，新型艾滋病疫苗在21世纪初已取得了相当大的成功。这些疫苗的一个共同特点是它们能够诱导高频CD8 + T细胞反应，从而控制而非预防HIV感染。新型疫苗包括DNA疫苗和活病毒载体，它们基于自艾滋病流行开始以来所开发的技术。只有在进行人体疗效试验后，这些疫苗的最终前景才能实现。
