Van Gelder Russell N
Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA.
J Biol Rhythms. 2002 Apr;17(2):110-20. doi: 10.1177/074873002129002401.
Cryptochromes are a family of flavoproteins found in organisms ranging from Arabidopsis to man. Across phylogeny, these proteins have been used for pleiotropic functions ranging from blue-light-dependent development in plants and blue-light-mediated phase shifting of the circadian clock in insects to a core circadian clock component in mammals. Review of the roles of cryptochromes in model organisms reveals several common themes: Multiple cryptochrome family members within individual organisms have redundant functions; cryptochromes used in photic entrainment pathways of the circadian clock are partially redundant with other photopigments; and cryptochromes may function in circadian phototransduction and core clock mechanisms in the same organism, with different functions in different tissues. The present review summarizes recent research on the functions of cryptochrome in the circadian timekeeping and photic entrainment pathways.
隐花色素是一类黄素蛋白，存在于从拟南芥到人类的各种生物体中。在整个系统发育过程中，这些蛋白质具有多种功能，从植物中依赖蓝光的发育、昆虫中蓝光介导的生物钟相位转变到哺乳动物中的核心生物钟成分。对隐花色素在模式生物中的作用进行综述，揭示了几个共同主题：个体生物体内的多个隐花色素家族成员具有冗余功能；生物钟光诱导途径中使用的隐花色素与其他光色素部分冗余；隐花色素可能在同一生物体的生物钟光转导和核心生物钟机制中发挥作用，在不同组织中具有不同功能。本综述总结了关于隐花色素在生物钟计时和光诱导途径中的功能的最新研究。
