Vincent Jean-Louis, Yagushi Arino, Pradier Olivier
Department of Intensive Care, Erasme University Hospital, Free University of Brussels, Belgium.
Crit Care Med. 2002 May;30(5 Suppl):S313-7. doi: 10.1097/00003246-200205001-00022.
To evaluate platelet function in sepsis.
The MEDLINE database and bibliographies of selected articles.
The common occurrence of thrombocytopenia in critically ill patients has been recognized for many years and is known to be associated with an increased mortality rate. Platelet function can be divided into four areas: activation, adhesion, aggregation, and secretion. Studies have found that activated platelets secrete key components of the coagulation and inflammatory cascades and are involved in the regulation of vascular tone. However, studies on platelet function in sepsis have been scarce, and their data are often conflicting. In sepsis, aggregation of circulating platelets seems to be reduced, yet platelet receptors are present in normal amounts.
Platelets play a complex role in sepsis; they are able to modulate not only their own function but also that of cells around them. Further study is needed to better define the precise mechanisms and effects of platelet activation in sepsis and to determine the benefits and risks of inhibiting platelet function.
评估脓毒症中的血小板功能。
MEDLINE数据库及所选文章的参考文献。
重症患者中血小板减少症的普遍存在已被认识多年，并且已知与死亡率增加相关。血小板功能可分为四个方面：激活、黏附、聚集和分泌。研究发现，活化的血小板分泌凝血和炎症级联反应的关键成分，并参与血管张力的调节。然而，关于脓毒症中血小板功能的研究很少，且其数据常常相互矛盾。在脓毒症中，循环血小板的聚集似乎减少，但血小板受体数量正常。
血小板在脓毒症中发挥着复杂的作用；它们不仅能够调节自身功能，还能调节周围细胞的功能。需要进一步研究以更好地界定脓毒症中血小板激活的确切机制和作用，并确定抑制血小板功能的益处和风险。
