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[骨包虫病。基于6例解剖临床观察]

[Osseous echinococcosis. Apropos of 6 anatomo-clinical observations].

作者信息

Abelanet R, Forest M, Palangié A, Meary R, Tomeno B, Languepin A

出版信息

Ann Anat Pathol (Paris). 1975 Mar-Apr;20(2):133-48.

PMID:1200429
Abstract

Concerning these six cases, the authors recall the rarity of osseous localization of Hydatidiform disease, isolated as a rule, arising in the adult and preferentially involving the ilium, spinal column, femur, humerus and scapula. Being slowly progressive, the condition is revealed by pain, swelling and above all spontaneous fractures (long bones), or signs of root or medullary compression (spinal column), followed sometimes by fistula formation. Radiological diagnosis is often difficult with an osteolytic appearance without appreciable reactional osteogenesis. As for laboratory investigations, they are only of value in orientation; immunofluorescence being the weakest. The extent of osseous lysis frequently demands extensive surgery. From the anatomical standpoint, the hydatid variety of Echinococcosis has a specific intra-osseous development: beginning in the spongy bone, the architecture is intermediary between the hydatid appearance and the alveolar variety. Some cases however comprise a unilocular appearance with a suspicion of adventitial reaction. Extension into the soft parts frequently adopts a macroscopic appearance identical with that of visceral forms. Bony lysis is dependant on osteoclastic resorption or foci of necrosis while reactional osteogenesis is reduced. Medullary cellular reactions are determinant in the anatomical progress: osteitis or histiocyte and plasmodial reaction to the cuticle fragments.

摘要

关于这6例病例,作者回顾了葡萄胎疾病骨定位的罕见性,通常为孤立性,发生于成年人,优先累及髂骨、脊柱、股骨、肱骨和肩胛骨。病情进展缓慢,表现为疼痛、肿胀,尤其是长骨的自发性骨折,或神经根或脊髓受压的体征(脊柱),有时随后会形成瘘管。骨质溶解的表现而无明显的反应性骨生成,影像学诊断往往困难。至于实验室检查,仅在诊断方向上有价值;免疫荧光检测结果最差。骨溶解的范围常常需要进行广泛的手术。从解剖学角度来看,棘球蚴病的包虫型在骨内有特定的发展过程:始于松质骨,其结构介于包虫外观和肺泡型之间。然而,一些病例表现为单房外观,怀疑有外膜反应。向软组织的扩展通常呈现出与内脏型相同的宏观外观。骨溶解取决于破骨细胞吸收或坏死灶,而反应性骨生成减少。骨髓细胞反应在解剖学进展中起决定性作用:对表皮碎片的骨炎或组织细胞及疟原虫反应。

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