Kamiryo Takanori, Tada Kenji, Shiraishi Shoji, Shinojima Naoki, Nakamura Hideo, Kochi Masato, Kuratsu Jun-ichi, Saya Hideyuki, Ushio Yukitaka
Department of Neurosurgery, Kumamoto University Medical School, Japan.
J Neurosurg. 2002 May;96(5):815-22. doi: 10.3171/jns.2002.96.5.0815.
One of the most frequent genetic abnormalities found in patients with glioblastoma multiforme (GBM) is homozygous deletion of the p16 tumor suppressor gene. The authors investigated whether this deletion is associated with prognosis in patients with GBM.
In 46 adult patients with supratentorial GBM, homozygous deletion of the p16 gene in tumor DNA was examined using the multiplex polymerase chain reaction assay. The deletion was confirmed in 14 (30.4%) of 46 patients, eight (30.8%) of 26 men and six (30.0%) of 20 women. Cox proportional hazard regression analysis, adjusted for age at surgery, the Karnofsky Performance Scale score, extent of resection, and the MIB-1 labeling index. revealed that homozygous deletion of the p16 gene was significantly associated with overall survival and progression-free survival in men, but not in women.
The results of this study suggest that p16 homozygous deletion is a significant unfavorable prognostic factor in male patients with GBM.
在多形性胶质母细胞瘤（GBM）患者中发现的最常见的基因异常之一是p16肿瘤抑制基因的纯合缺失。作者研究了这种缺失是否与GBM患者的预后相关。
对46例幕上GBM成年患者，采用多重聚合酶链反应检测肿瘤DNA中p16基因的纯合缺失。46例患者中有14例（30.4%）证实存在缺失，其中男性26例中有8例（30.8%），女性20例中有6例（30.0%）。Cox比例风险回归分析对手术年龄、卡氏功能状态评分、切除范围和MIB-1标记指数进行了校正。结果显示，p16基因的纯合缺失与男性患者的总生存期和无进展生存期显著相关，但与女性患者无关。
本研究结果表明，p16纯合缺失是男性GBM患者一个显著的不良预后因素。
