Yang Xi, Wang Ji-Shu, Han Hua
Department of Medical Genetics and Developmental Biology, The Fourth Military Medical University, Xi'an 710032, China.
Sheng Wu Hua Xue Yu Sheng Wu Wu Li Xue Bao (Shanghai). 2002 Mar;34(2):231-5.
Tax is a transcription activator encoded by human T-cell leukemia virus (HTLV)-1. Ribosomal protein L6 was also defined as Taxreb107 (Tax responsible element binding protein 107) for its activity of binding to the long terminal repeats of HTLV-1. To investigate the relationship between Tax and Taxreb107/RpL6, yeast two hybrid and GST pull-down assays were used. Results suggest that Tax can interact with Taxreb107/RpL6 directly and Taxreb107/RpL6 may regulate the function of Tax in HTLV-1 proliferation.
Tax是一种由人类T细胞白血病病毒（HTLV）-1编码的转录激活因子。核糖体蛋白L6因其与HTLV-1长末端重复序列的结合活性，也被定义为Taxreb107（Tax反应元件结合蛋白107）。为了研究Tax与Taxreb107/RpL6之间的关系，采用了酵母双杂交和GST下拉实验。结果表明，Tax可直接与Taxreb107/RpL6相互作用，且Taxreb107/RpL6可能在HTLV-1增殖过程中调节Tax的功能。
