Sears D A, George J N, Gold M S
Arch Intern Med. 1975 Dec;135(12):1585-9.
Transient pure red blood cell aplasia was verified during the course of viral hepatitis in two siblings whose illnesses occurred four years apart. The duration and course of the anemia was very similar in the two subjects, and in both the hepatitis progressed to a chronic active form. Autoimmune phenomena were prominent in one patient and suggested in the other, but a cytotoxic antibody to erythroblasts could not be demonstrated in the one patient in whom it was sought. The unique occurrence of such a syndrome in siblings, widely separated in time, suggests the possibility of a genetic predisposition governing the unusual response to a common illness.
在相隔四年发病的两名同胞病毒性肝炎患者病程中，均证实有短暂性纯红细胞再生障碍。两名患者贫血的持续时间和病程非常相似，且两人的肝炎均进展为慢性活动型。自身免疫现象在一名患者中很突出，在另一名患者中也有提示，但在其中一名进行检测的患者中未发现抗成红细胞的细胞毒性抗体。这种综合征在时间上相隔甚远的同胞中独特出现，提示可能存在一种遗传易感性，决定了对常见疾病的异常反应。
