Fry Christopher H, Skennerton Deborah, Wood Dan, Wu Changhao
Institute of Urology & Nephrology, University College London, London, United Kingdom.
Urology. 2002 May;59(5 Suppl 1):3-12. doi: 10.1016/s0090-4295(01)01632-6.
Studying the cellular physiology of human detrusor muscle obtained from patients with normally functioning bladders and comparing it with that of detrusor muscle from patients with unstable bladders may help identify potential targets for drug therapy in patients with abnormal bladder function. Considerable advances have been made in the understanding of the cellular processes that result in contraction and relaxation of detrusor smooth muscle, particularly in the role and modulation of calcium. Several changes in these cellular mechanisms that impair normal function have been observed in detrusor muscle from patients with unstable bladders. Whether these changes represent primary causes of bladder dysfunction or whether they are secondary to bladder dysfunction remains to be determined. Nevertheless, the identification of specific cellular lesions in bladder dysfunction presents a novel approach to identification of drug targets and potential treatment modalities.
研究从膀胱功能正常的患者获取的人类逼尿肌的细胞生理学，并将其与不稳定膀胱患者的逼尿肌进行比较，可能有助于确定膀胱功能异常患者药物治疗的潜在靶点。在理解导致逼尿肌平滑肌收缩和舒张的细胞过程方面已经取得了相当大的进展，特别是在钙的作用和调节方面。在不稳定膀胱患者的逼尿肌中观察到这些损害正常功能的细胞机制有几种变化。这些变化是代表膀胱功能障碍的主要原因还是继发于膀胱功能障碍仍有待确定。然而，识别膀胱功能障碍中的特定细胞损伤为确定药物靶点和潜在治疗方式提供了一种新方法。
