Weigel B, Hammer H J, Ziegan J
Z Gesamte Inn Med. 1979 Sep 1;34(17):490-4.
The observation of multiple ossifications in the lungs as secondary findings of the post-mortem examination of a 62-year-old male with chronic cardiac stasis and emphysema of the lung is reported. Apart from bone nodules larger branched mature bone clasps with marrow caves as well as a in most cases fibromatosis with a small focus which represents the matrix of ossification is represented. Apart from this histologically a hyperaemia with an oedema rich in protein, focal precipitation of protein with formation of a granulation tissue and later fibrosation are to be proved as presteps of nodular fibromatosis which according to the kind of the desmal ossification changes into bones. The chronic haemostasis in the pulmonary circulation is thus apparently of importance in our observation. The case is compared with literature. Up to now about 65 of such observations are reported which nearly exclusively concern old men. The etiology remains unclear.
报告了在一名患有慢性心源性瘀血和肺气肿的62岁男性尸体解剖中发现肺部多处骨化的情况。除了骨结节外，还发现了带有骨髓腔的较大分支成熟骨扣，以及在大多数情况下伴有小病灶的纤维瘤病，该小病灶代表骨化基质。除此之外，组织学上可见充血伴富含蛋白质的水肿、蛋白质局灶性沉淀并形成肉芽组织，随后纤维化，这些被证明是结节性纤维瘤病的前期步骤，根据骨化的类型，结节性纤维瘤病会转变为骨骼。因此，在我们的观察中，肺循环中的慢性瘀血显然很重要。该病例与文献进行了比较。到目前为止，已报告了约65例此类观察结果，几乎均涉及老年男性。病因仍不清楚。
