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Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver.3-巯基吡啶甲酸对离体灌注大鼠肝脏糖异生及糖异生代谢物浓度的影响。
Biochem J. 1975 Jul;150(1):137-9. doi: 10.1042/bj1500137.
2
3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.3-巯基吡啶甲酸，一种糖异生抑制剂。
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3
Mechanism of 3-mercaptopicolinic acid inhibition of hepatic phosphoenolpyruvate carboxykinase (GTP).3-巯基吡啶甲酸对肝脏磷酸烯醇式丙酮酸羧激酶（GTP）的抑制机制。
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Inhibition of gluconeogenesis in isolated rat hepatocytes after chronic treatment with phenobarbital.苯巴比妥长期处理后对分离的大鼠肝细胞糖异生的抑制作用。
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Rate-limiting steps in metabolic pathways.
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3-Aminopicolinate inhibits phosphoenolpyruvate carboxykinase in hepatocytes and increases release of gluconeogenic precursors from peripheral tissues.3-氨基吡啶甲酸抑制肝细胞中的磷酸烯醇丙酮酸羧激酶，并增加外周组织中糖异生前体的释放。
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Gluconeogenesis in isolated hepatic parenchymal cells. VII. Effects of monobutyryl cyclic adenosine monophosphate on gluconeogenic intermediates, phosphofructokinase, and fructose diphosphatase.离体肝实质细胞中的糖异生作用。VII. 单丁酰环磷酸腺苷对糖异生中间产物、磷酸果糖激酶和果糖二磷酸酶的影响。
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Hyperglycaemic activity and metabolic effects of 3-aminopicolinic acid.3-氨基吡啶甲酸的高血糖活性及代谢效应
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9
Prolone metabolism in isolated rat liver cells.原洛酮在离体大鼠肝细胞中的代谢。
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本文引用的文献

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Influence of L-tryptophan and its metabolites on gluconeogenesis in the isolated, perfused liver.L-色氨酸及其代谢产物对离体灌注肝脏糖异生的影响。
Biochemistry. 1967 Jul;6(7):2129-38. doi: 10.1021/bi00859a034.
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Alteration of rat liver phosphoenolpyruvate carboxykinase activity by L-tryptophan in vivo and metals in vitro.L-色氨酸在体内及金属离子在体外对大鼠肝脏磷酸烯醇式丙酮酸羧激酶活性的影响。
Biochemistry. 1967 Jul;6(7):2120-8. doi: 10.1021/bi00859a033.
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Paths of carbon in gluconeogenesis and lipogenesis. IV. Inhibition by L-tryptophan of hepatic gluconeogenesis at the level of phosphoenolpyruvate formation.
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Influence of fluorocarbon emulsions on hepatic metabolism in perfused rat liver.
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3-mercaptopicolinic acid, an inhibitor of gluconeogenesis.3-巯基吡啶甲酸，一种糖异生抑制剂。
Biochem J. 1974 Mar;138(3):387-94. doi: 10.1042/bj1380387.
6
The regulation of gluconeogenesis. The effect of pent-4-enoic acid on gluconeogenesis and on the gluconeogenic metabolite concentrations of isolated perfused rat liver.糖异生的调节。戊-4-烯酸对糖异生及离体灌注大鼠肝脏糖异生代谢物浓度的影响。
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3-巯基吡啶甲酸对离体灌注大鼠肝脏糖异生及糖异生代谢物浓度的影响。

Effect of 3-mercaptopicolinic acid on gluconeogenesis and gluconeogenic metabolite concentrations in the isolated perfused rat liver.

作者信息

Goodman M N

出版信息

Biochem J. 1975 Jul;150(1):137-9. doi: 10.1042/bj1500137.

DOI:10.1042/bj1500137
PMID:1201006
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1165714/
Abstract

3-Mercaptopicolinic acid inhibited gluconeogenesis from lactate and alanine, but not dihydroxyacetone, in the perfused rat liver. Hepatic metabolite concentrations suggested that gluconeogenesis was inhibited at phosphoenolpyruvate carboxykinase. The compound is very effective at low concentrations, and seems an ideal agent for use in studying metabolic regulation involving gluconeogenesis and anaplerotic mechanisms.

摘要

3-巯基吡啶甲酸在灌注大鼠肝脏中抑制了由乳酸和丙氨酸生成葡萄糖的糖异生过程，但对二羟丙酮生成葡萄糖的过程没有抑制作用。肝脏代谢物浓度表明，糖异生在磷酸烯醇式丙酮酸羧激酶处受到抑制。该化合物在低浓度时非常有效，似乎是用于研究涉及糖异生和回补机制的代谢调节的理想试剂。