Cohen Jack B
Department of Dermatology, Univ. of Texas Southwestern Medical School, 5323 Harry Hines Boulevard, Dallas, TX 75390-9190, USA.
Int J Dermatol. 2002 Mar;41(3):182-4. doi: 10.1046/j.1365-4362.2002.01409.x.
Dapsone (4,4-diaminodiphenylsulfone) is a sulfone antibiotic used in the treatment of leprosy, but dermatologists more commonly utilize its anti-inflammatory properties particularly directed against leukocytes to treat various bullous disorders, erythema nodosum, pyoderma gangrenosum, Sweet's syndrome, cutaneous vasculitis, and cutaneous forms of lupus erythematosus. The cutaneous manifestations of dermatomyositis are often resistant to antimalarial and immunosuppressive therapies.
Two patients with cutaneous dermatomyositis unresponsive to combination therapy with prednisone, hydroxychloroquine, quinacrine, and immunosuppressive medications had Dapsone added to their therapy.
Both patients showed rapid improvement with the addition of Dapsone. Each had an exacerbation of their cutaneous dermatomyositis on Dapsone with withdrawal and subsequent improvement when the Dapsone was reinstituted.
Dapsone therapy for cutaneous dermatomyositis may have a wider role in treatment for these patients refractory to prednisone and antimalarial therapy.
氨苯砜（4,4-二氨基二苯砜）是一种用于治疗麻风病的砜类抗生素，但皮肤科医生更常利用其抗炎特性，特别是针对白细胞的特性，来治疗各种大疱性疾病、结节性红斑、坏疽性脓皮病、Sweet综合征、皮肤血管炎以及皮肤型红斑狼疮。皮肌炎的皮肤表现通常对抗疟药和免疫抑制疗法耐药。
两名皮肌炎患者对泼尼松、羟氯喹、奎纳克林和免疫抑制药物联合治疗无反应，在其治疗方案中加入了氨苯砜。
两名患者在加用氨苯砜后均迅速改善。两人在停用氨苯砜时皮肌炎病情均加重，重新使用氨苯砜后病情随后改善。
氨苯砜治疗皮肌炎可能在治疗这些对泼尼松和抗疟治疗无效的患者中发挥更广泛的作用。
