通过使用靶向ENO1基因座的带有可选标记URA3的白色念珠菌菌株重新评估HWP1在系统性念珠菌病中的作用。
Reevaluation of the role of HWP1 in systemic candidiasis by use of Candida albicans strains with selectable marker URA3 targeted to the ENO1 locus.
作者信息
Sundstrom Paula, Cutler Jim E, Staab Janet F
机构信息
Department of Molecular Virology, The Ohio State University College of Medicine and Public Health, Columbus, Ohio 43210, USA.
出版信息
Infect Immun. 2002 Jun;70(6):3281-3. doi: 10.1128/IAI.70.6.3281-3283.2002.
Abstract
Previous evaluation of HWP1 in systemic candidiasis in CBA/J mice was done with Candida albicans strains with differing genetic locations of URA3 as a result of Ura-blaster mutagenesis. In this study, the presence of HWP1 and the location of URA3 contributed to the severity of murine systemic candidiasis in BALB/c mice.
摘要
先前在CBA/J小鼠的系统性念珠菌病中对HWP1的评估是使用因URA3基因敲除诱变而具有不同URA3基因位置的白色念珠菌菌株进行的。在本研究中，HWP1的存在和URA3的位置导致了BALB/c小鼠系统性念珠菌病的严重程度。
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