牙龈卟啉单胞菌的精氨酸特异性半胱氨酸蛋白酶对人牙龈成纤维细胞上CD14的蛋白水解作用导致脂多糖诱导的白细胞介素-8产生下调。
Proteolysis of CD14 on human gingival fibroblasts by arginine-specific cysteine proteinases from Porphyromonas gingivalis leading to down-regulation of lipopolysaccharide-induced interleukin-8 production.
作者信息
Tada Hiroyuki, Sugawara Shunji, Nemoto Eiji, Takahashi Nobuhiro, Imamura Takahisa, Potempa Jan, Travis James, Shimauchi Hidetoshi, Takada Haruhiko
机构信息
Department of Microbiology and Immunology, Tohoku University School of Dentistry, Sendai 980-8575, Japan.
出版信息
Infect Immun. 2002 Jun;70(6):3304-7. doi: 10.1128/IAI.70.6.3304-3307.2002.
Abstract
Arginine-specific cysteine proteinases (gingipains-R) from periodontopathic Porphyromonas gingivalis cleaved CD14, a bacterial pattern recognition receptor, on human gingival fibroblasts (HGF). Consequently, gingipains-R reduced lipopolysaccharide-induced interleukin-8 production by HGF, indicating that gingipains-R inhibited CD14-dependent HGF activation and are involved in immune evasion by the bacterium in periodontal tissues.
摘要
来自牙周病原菌牙龈卟啉单胞菌的精氨酸特异性半胱氨酸蛋白酶（牙龈蛋白酶-R）可切割人牙龈成纤维细胞（HGF）上的细菌模式识别受体CD14。因此，牙龈蛋白酶-R可减少HGF产生的脂多糖诱导的白细胞介素-8，这表明牙龈蛋白酶-R抑制了CD14依赖性HGF激活，并参与了该细菌在牙周组织中的免疫逃逸。
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