Vance J P, Smith G, Thorburn J, Brown D M
Br J Anaesth. 1975 Aug;47(8):825-9. doi: 10.1093/bja/47.8.825.
In eleven intact mechanically ventilated dogs anaesthetized with pentobarbitone, mean arterial pressure was reduced to 55% of the control value by ventilating with 1-1.5% halothane. At normocapnia this resulted in decreases in myocardial blood-flow and oxygen consumption to 47% and 55% of their respective control values and an increase in myocardial vascular resistance to 123% of control value. When hypocapnia (mean PaCO2=26 mm Hg) was superimposed on hypotension, myocardial blood-flow was further decreased to 38% of control value whereas oxygen consumption did not alter significantly. When halothane was discontinued, allowing recovery from hypotension, the rate of recovery of myocardial blood-flow and cardiac output was much slower than that of arterial pressure.
在11只使用戊巴比妥麻醉的完整机械通气犬中，通过用1-1.5%的氟烷通气，平均动脉压降至对照值的55%。在正常二氧化碳分压时，这导致心肌血流量和氧耗分别降至各自对照值的47%和55%，心肌血管阻力增加至对照值的123%。当低碳酸血症（平均动脉血二氧化碳分压=26mmHg）叠加于低血压时，心肌血流量进一步降至对照值的38%，而氧耗无显著改变。当停用氟烷，使低血压恢复时，心肌血流量和心输出量的恢复速度比动脉压的恢复速度慢得多。
