Adeyemo Adebowale A, Omotade Olayemi O, Rotimi Charles N, Luke Amy H, Tayo Bamidele O, Cooper Richard S
College of Medicine, University of Ibadan, Ibadan, Nigeria.
J Hypertens. 2002 May;20(5):859-63. doi: 10.1097/00004872-200205000-00019.
There are few studies of familial aggregation of blood pressure in African populations. This study was undertaken to provide estimates of heritability for four blood pressure phenotypes: systolic blood pressure (SBP), diastolic blood pressure (DBP), mean arterial pressure (MAP) and pulse pressure.
A population-based sample of 528 pedigrees or extended families, comprising 1825 measured individuals, was studied in a poor urban community in Ibadan, Nigeria.
The mean SBP was 121.7 (SD 22.6) mmHg for men and 120.7 (SD 26.8) mmHg for women, while the mean DBP was 74.6 (SD 14.1) mmHg for men and 75.5 (SD 15.2) mm Hg for women. The study sample was lean [mean body mass index (BMI) approximately 21 kg/m2]. Maximum-likelihood heritability estimates were obtained under a polygenic model with simultaneous estimation of household effects using a variance components method, as implemented in the SOLAR software package. Heritability estimates of the traits were 34% for SBP, 29% for DBP, 36% for MAP and 13% for pulse pressure. Household effects were statistically significant for DBP (7.1%) and MAP (4.5%). Measured covariates (age, sex and BMI) accounted for 25, 24, 26 and 16% of the total variance, respectively, for SBP, DBP, MAP and pulse pressure.
These figures suggest that, similar to that reported in other populations, blood pressure is a heritable trait. Studies similar to this are needed to describe the familial aggregation of other complex traits in sub-Saharan African populations and to serve as a prelude to the identification of susceptibility genes involved in the pathophysiology of common complex diseases, including blood pressure and hypertension.
针对非洲人群血压的家族聚集性开展的研究较少。本研究旨在对四种血压表型的遗传力进行估计，这四种表型分别为收缩压（SBP）、舒张压（DBP）、平均动脉压（MAP）和脉压。
在尼日利亚伊巴丹的一个贫困城市社区，对一个基于人群的样本进行了研究，该样本包含528个家系或大家庭，共计1825名被测个体。
男性的平均收缩压为121.7（标准差22.6）mmHg，女性为120.7（标准差26.8）mmHg；男性的平均舒张压为74.6（标准差14.1）mmHg，女性为75.5（标准差15.2）mmHg。研究样本体型偏瘦[平均体重指数（BMI）约为21kg/m²]。使用SOLAR软件包中实现的方差分量法，在一个同时估计家庭效应的多基因模型下，获得了最大似然遗传力估计值。这些性状的遗传力估计值分别为：收缩压34%、舒张压29%、平均动脉压36%、脉压13%。家庭效应在舒张压（7.1%）和平均动脉压（4.5%）方面具有统计学意义。测量的协变量（年龄、性别和BMI）分别占收缩压、舒张压、平均动脉压和脉压总方差的25%、24%、26%和16%。
这些数据表明，与其他人群的报告情况类似，血压是一种可遗传的性状。需要开展类似本研究的工作，以描述撒哈拉以南非洲人群中其他复杂性状的家族聚集性，并为鉴定参与包括血压和高血压在内的常见复杂疾病病理生理学的易感基因奠定基础。
