Kernoff L M, Dommisse J, du Toit E D
Br J Haematol. 1975 Aug;30(4):419-24. doi: 10.1111/j.1365-2141.1975.tb01856.x.
Previously published studies have documented a reduction in the rate at which iron stores laid down by iron dextran therapy can be utilized for haemoglobin synthesis after the acute demands of haemorrhage and phlebotomy. In order to determine if a defect in the mobilization of these stores exists in the face of a chronic stimulus to red cell production, 93 patients who had previously received a total dose infusion of iron dextran were examined for a recurrence of iron deficiency anaemia, and in those in whom anaemia had recurred, iron stores were assessed by marrow aspiration. Twenty of the 93 patients were found to have recurrent iron deficiency anaemia, and marrow aspiration in all failed to demonstrate stainable iron stores. Although the rate at which iron dextran can be mobilized from storage sites is reduced, the present study demonstrates that ultimately these stores are fully utilizable.
先前发表的研究记录了在出血和放血的急性需求后，右旋糖酐铁疗法储存的铁用于血红蛋白合成的速率降低。为了确定在面对慢性红细胞生成刺激时，这些储存铁的动员是否存在缺陷，对93名先前接受过总剂量右旋糖酐铁输注的患者进行了缺铁性贫血复发检查，对于那些贫血复发的患者，通过骨髓穿刺评估铁储备。93名患者中有20名被发现患有复发性缺铁性贫血，所有患者的骨髓穿刺均未显示可染色的铁储备。尽管右旋糖酐铁从储存部位动员的速率降低，但本研究表明，最终这些储备铁是完全可用的。
