Zittoun J, Marquet J, Zittoun R
Br J Haematol. 1975 Nov;31(3):299-310. doi: 10.1111/j.1365-2141.1975.tb00861.x.
A study of the three serum transcobalamins (TC) in myeloproliferative disorders and acute leukaemia has suggested a granulocyte origin for the three binders; the later stages of this cell line might be releasing 'TC I' and 'TC III' while 'TC II' which is increased in sera from patients with acute myelogenous leukaemia, probably originates at least in part from myeloblasts. The intracellular content of each TC has been studied in normal and leukaemic bone marrow cells after separation on a discontinuous bovine serum albumin gradient. Myeloblasts contain a TC II-like protein almost exclusively but promyelocytes contain a TC I-like protein which increases as the cells mature whilst 'TC II' decreases. A TC III-like binder parallels 'TC I' but appears later and reaches a maximum in the polymorphonuclear cells. In various types of leukaemia, abnormal TC distributions are related either to marrow replacement by the blast cells or to a disorder of the maturation process in the leukaemic cell line.
一项对骨髓增殖性疾病和急性白血病中三种血清转钴胺素（TC）的研究表明，这三种结合蛋白起源于粒细胞；该细胞系的后期阶段可能释放“TC I”和“TC III”，而急性髓性白血病患者血清中增加的“TC II”可能至少部分起源于成髓细胞。在通过不连续牛血清白蛋白梯度分离后的正常和白血病骨髓细胞中，对每种TC的细胞内含量进行了研究。成髓细胞几乎只含有一种类似TC II的蛋白质，但早幼粒细胞含有一种类似TC I的蛋白质，随着细胞成熟其含量增加，而“TC II”减少。一种类似TC III的结合蛋白与“TC I”平行，但出现较晚，在多形核细胞中达到最大值。在各种类型的白血病中，异常的TC分布要么与原始细胞对骨髓的替代有关，要么与白血病细胞系成熟过程的紊乱有关。
