熊去氧胆酸治疗新生儿杜宾-约翰逊综合征的严重胆汁淤积症

Treatment of severe cholestasis in neonatal Dubin-Johnson syndrome with ursodeoxycholic acid.

作者信息

Regev Rivka H, Stolar Orit, Raz Aryeh, Dolfin Tzipora

机构信息

Neonatal Department, Meir Hospital, Sapir Medical Center, Kfar Saba, Israel.

出版信息

J Perinat Med. 2002;30(2):185-7. doi: 10.1515/JPM.2002.025.

DOI:10.1515/JPM.2002.025

PMID:12012642

Abstract

We report a case of Dubin-Johnson Syndrome in a neonate presenting with severe direct hyperbilirubinemia, which failed to respond to phenobarbital treatment. Ursodeoxycholic Acid added to therapy was well tolerated, and resulted in declining bilirubin concentration. We suggest ursodeoxycholic acid in treatment for Dubin-Johnson Syndrome with severe direct hyperbilirubinemia presenting in the neonatal age.

摘要

我们报告了一例患有严重直接胆红素血症的新生儿杜宾-约翰逊综合征病例，该病例对苯巴比妥治疗无反应。添加到治疗中的熊去氧胆酸耐受性良好，并导致胆红素浓度下降。我们建议熊去氧胆酸用于治疗新生儿期出现的伴有严重直接胆红素血症的杜宾-约翰逊综合征。