重新审视LEW/Crj、Slc/Wistar/ST和Slc/SD大鼠对佐剂诱导性关节炎易感性的差异。
Reexamination of the difference in susceptibility to adjuvant-induced arthritis among LEW/Crj, Slc/Wistar/ST and Slc/SD rats.
作者信息
Banik Ratan Kumar, Kasai Masanori, Mizumura Kazue
机构信息
Department of Neural Regulation, Research Institute of Environmental Medicine, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8601, Japan.
出版信息
Exp Anim. 2002 Apr;51(2):197-201. doi: 10.1538/expanim.51.197.
The present investigations were performed to assess the differences among rat colonies commonly used for neurophysiological research regarding the development of complete Freund's adjuvant (CFA)-induced arthritis. Inflammatory signs including edema in the paw fluctuated remarkably among individual Wistar (Slc/Wistar/ST) and Sprague-Dawley (Slc/SD) rats, while the inflammatory signs of Lewis (LEW/Crj) rats appeared earlier and was severer and more consistent than Slc/Wistar/ST and Slc/SD rats. Edema in the hind paw developed in 100% of LEW/Crj rats with the lowest dose of CFA (0.6 mg/rat) used as compared with 64% of Slc/Wistar/ST (CFA 1 mg/rat) and 38% of Slc/SD rats (CFA 1.2 mg/rat). Retardation of weight gain was observed in Slc/Wistar/ST and Slc/SD rats in contrast to a severe weight decrease in inflamed LEW/Crj rats after the development of arthritis.
本研究旨在评估常用于神经生理学研究的大鼠群体在完全弗氏佐剂（CFA）诱导的关节炎发展方面的差异。包括爪部水肿在内的炎症迹象在个体Wistar（Slc/Wistar/ST）和Sprague-Dawley（Slc/SD）大鼠之间波动显著，而Lewis（LEW/Crj）大鼠的炎症迹象出现得更早，且比Slc/Wistar/ST和Slc/SD大鼠更严重、更一致。与64%的Slc/Wistar/ST大鼠（CFA 1mg/只）和38%的Slc/SD大鼠（CFA 1.2mg/只）相比，使用最低剂量CFA（0.6mg/只）时，100%的LEW/Crj大鼠后爪出现水肿。与Slc/Wistar/ST和Slc/SD大鼠体重增加迟缓相反，关节炎发展后，发炎的LEW/Crj大鼠体重严重下降。
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