催乳素在选定大鼠器官和组织中的分布。
Distribution of prolactin in selected rat organs and tissues.
作者信息
Ryszka F, Dolińska B, Suszka-Switek A
机构信息
Department of Applied Pharmacy and Drug Technology, Silesian Medical Academy, Sosnowiec, Poland.
出版信息
Int J Tissue React. 2002;24(1):33-6.
A single dose of 25 microg prolactin (PRL)/kg of rat body weight was administered to rats subcutaneously. At 1, 2, 3, 4 and 5 h after the injection, selected organs and tissues were taken for analysis. It was found that 1 h after administration, the highest amount of PRL accumulated in the milk (lactiferous) gland, the blood, the ovaries, the pituitary and the liver. Over time, the prolactin content in the selected organs and tissues decreased. PRL is selectively captured by the milk gland, the pituitary, the ovaries, the liver and the heart. Based on the value of the organ or tissue capacity index for PRL, the following order was established for the organs and tissues to which the hormone binds: milk gland > blood > pituitary > ovaries > lungs > liver > cranial bone > spleen > heart > kidneys > muscular tissue > adrenals > adipose tissue > brain.
给大鼠皮下注射单剂量25微克催乳素（PRL）/千克大鼠体重。在注射后1、2、3、4和5小时，选取器官和组织进行分析。结果发现，给药后1小时，PRL在乳腺（泌乳腺）、血液、卵巢、垂体和肝脏中积累量最高。随着时间推移，所选器官和组织中的催乳素含量下降。PRL被乳腺、垂体、卵巢、肝脏和心脏选择性摄取。根据PRL的器官或组织容量指数值，确定了该激素结合的器官和组织顺序如下：乳腺＞血液＞垂体＞卵巢＞肺＞肝脏＞颅骨＞脾脏＞心脏＞肾脏＞肌肉组织＞肾上腺＞脂肪组织＞脑。
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