Barraja Paola, Diana Patrizia, Lauria Antonino, Montalbano Alessandra, Almerico Anna Maria, Dattolo Gaetano, Cirrincione Girolamo
Dipartimento Farmacochimico Tossicologico e Biologico, Università degli Studi, Palermo, Italy.
Anticancer Res. 2002 Mar-Apr;22(2A):837-40.
A series of 2-triazenoindole derivatives was prepared in moderate to good yields by coupling 2-diazoindoles with secondary amines. Only 3-ethoxycarbonyl-2-(3.3-tetramethylenetriazenyl)-indole, tested against a panel of 60 human tumor cell lines, showed moderate activity on breast, ovarian and CNS cancer with GI50 in the range 23-36 microM.
通过将2-重氮吲哚与仲胺偶联，以中等至良好的产率制备了一系列2-三氮烯吲哚衍生物。仅3-乙氧羰基-2-(3,3-四亚甲基三氮烯基)-吲哚在针对60种人类肿瘤细胞系的测试中，对乳腺癌、卵巢癌和中枢神经系统癌表现出中等活性，GI50在23-36微摩尔范围内。
