Suresh R L, Merican I, Chang K M, Yong S M, Purusothaman V
Department of Medicine, Hospital Kuala Lumpur.
Med J Malaysia. 2001 Dec;56(4):508-11.
In the setting of transplantation and chronic hepatitis B viral infection there is a unique histological feature termed cholestatic fibrosing hepatitis. The use of nucleoside analogues in the treatment of this condition has been successful. We describe a case of cholestatic fibrosing hepatitis, which occurred after intense immunosuppression for graft versus host disease in a patient with bone marrow transplantations. She was commenced on lamivudine therapy and showed good clinical, biochemical and virological response. However she succumbed due to sepsis.
在移植及慢性乙型肝炎病毒感染的情况下，存在一种独特的组织学特征，称为胆汁淤积性纤维化性肝炎。核苷类似物用于治疗这种疾病已取得成功。我们描述了一例胆汁淤积性纤维化性肝炎病例，该病例发生在一名接受骨髓移植的患者因移植物抗宿主病接受强化免疫抑制治疗之后。她开始接受拉米夫定治疗，临床、生化及病毒学反应良好。然而，她最终因败血症死亡。
