人类早衰疾病沃纳综合征中存在缺陷的通路。

Pathways defective in the human premature aging disease Werner syndrome.

作者信息

Bohr Vilhelm A, Brosh Robert M, von Kobbe Cayetano, Opresko Patricia, Karmakar Parimal

机构信息

Laboratory of Molecular Gerontology, National Institute on Aging, NIH, Baltimore, MD 21224, USA.

出版信息

Biogerontology. 2002;3(1-2):89-94. doi: 10.1023/a:1015223917491.

DOI:10.1023/a:1015223917491

PMID:12014850

Abstract

Werner syndrome is the hallmark premature aging disease, where the patients appear much older than their chronological age. The Werner protein, defective in this disorder, is a DNA helicase and an exonuclease, and it participates in pathways of DNA repair, recombination, transcription and replication. The function and role of this protein is discussed in the light of how it functions in the aging process.

摘要

沃纳综合征是典型的早衰疾病，患者看起来比其实际年龄苍老得多。在这种疾病中存在缺陷的沃纳蛋白是一种DNA解旋酶和核酸外切酶，它参与DNA修复、重组、转录和复制过程。本文将根据该蛋白在衰老过程中的作用方式来探讨其功能和作用。