Liu Xiangfan, Wang Xuefeng, Fan Qishi, Chu Haiyan, Fang Yi, Wang Hongli
Shanghai Ruijin Hospital, Shanghai Institute of Hematology, Shanghai 200025, China.
Zhonghua Xue Ye Xue Za Zhi. 2002 Mar;23(3):147-50.
To establish a simple, rapid genetic diagnostic system for haemophilia B.
The polymorphisms of eight STR loci in 87 normal persons and 8 haemophilia B families were assayed by PCR and genescan, and the linkage relations were analysed.
Six of the eight STR loci can provide genetic information for haemophilia B, and the heterozygosity is 0.50 approximately 0.83, PIC 0.39 approximately 0.80, and DP 0.66 approximately 0.94.
Combination of multiple STR loci analysis could be effective method for genetic diagnosis of haemophilia B.
