[福州市健康学龄前儿童口腔咽部流感嗜血杆菌携带状况研究]

[Study on the status of oral pharyngeal carriage of Haemophilus influenzae in healthy preschool children in Fuzhou city].

作者信息

Lai Guoxiang, Zhang Hongwen, Ye Liyan, Huang Lianghu, Lin Maoying, Cao Huiqin, Chen Xinmin

机构信息

Department of Respiratory Disease. Fuzhou Military General Hospital, Fuzhou 350025, China.

出版信息

Zhonghua Liu Xing Bing Xue Za Zhi. 2002 Apr;23(2):108-10.

PMID:12015091

Abstract

OBJECTIVE

To study the status of oral pharyngeal carriage and characteristics of Haemophilus influenzae (Hi) in healthy preschool children in Fuzhou.

METHODS

Six hundred and three healthy children in two representative kindergartens in Fuzhou were studied as research subjects, and the rates of oral pharyngeal carriage of Hi were studied in four seasons. All Hi strains were serotyped and biotyped.

RESULTS

The oral pharyngeal carriage of Hi in day care nursery healthy children were 36.7% in winter, 18.0% in autumn, 12.4% in summer and 10.9% in spring respectively. Serotype Hib was preponderant in autumn (6.9%). In winter, the carriage rates of NTHi and Hib were 17.1%, 5.4% respectively. The carriage rates of other serotypes were low. Biotype VII and VIII were preponderant in autumn, spring and summer but biotype VII and VIII were decreasing evidently in winter.

CONCLUSION

There was evident seasonal difference in the rates of oral pharyngeal carriage and type of Hi in healthy preschool children. The carriage rate of Hi strains was high in autumn and winter. Results suggested that while the inoculation of Hib-binding bacterial vaccine was expanded the study on new bacterial vaccine of Hi still needs to be augmented.

摘要

目的

研究福州地区健康学龄前儿童口咽部流感嗜血杆菌（Hi）携带状况及特征。

方法

选取福州两所具有代表性幼儿园的603名健康儿童作为研究对象，对其四季口咽部Hi携带率进行研究。对所有Hi菌株进行血清分型和生物分型。

结果

日托幼儿园健康儿童口咽部Hi携带率冬季为36.7%，秋季为18.0%，夏季为12.4%，春季为10.9%。秋季Hib血清型占优势（6.9%）。冬季非b型流感嗜血杆菌（NTHi）和Hib携带率分别为17.1%、5.4%。其他血清型携带率较低。生物型VII和VIII在秋季、春季和夏季占优势，但在冬季明显减少。