锌对乙醇喂养大鼠肝脏脂质过氧化及抗氧化酶的影响。
Effect of zinc on hepatic lipid peroxidation and antioxidative enzymes in ethanol-fed rats.
作者信息
Pathak A, Mahmood A, Pathak R, Dhawan D
机构信息
Department of Nuclear Medicine, PGIMER, Chandigarh, India.
出版信息
J Appl Toxicol. 2002 May-Jun;22(3):207-10. doi: 10.1002/jat.851.
A 3-ml aliquot of 30% ethanol was fed daily to normal as well as zinc-treated (227 mg l(-1)) rats for periods of 2, 4 and 8 weeks. A highly significant increase in the levels of hepatic lipid peroxidation was observed in ethanol-fed rats after 4 and 8 weeks of treatment. On the other hand, the levels of lipid peroxidation came down significantly following ethanol feeding to zinc-treated rats. The activities of glutathione peroxidase (GPx), catalase and superoxide dismutase (SOD) in liver were elevated significantly after ethanol administration to rats for durations of 2, 4 and 8 weeks. Interestingly, zinc treatment to rats given ethanol was able to bring down the elevated levels of SOD, catalase and GPx to within normal limits, However, zinc administration alone did not cause any significant alteration in the activities of these antioxidative enzymes.
将3毫升30%的乙醇每日喂食给正常大鼠以及经锌处理（227毫克/升）的大鼠，持续2周、4周和8周。在处理4周和8周后，观察到乙醇喂养的大鼠肝脏脂质过氧化水平显著升高。另一方面，给经锌处理的大鼠喂食乙醇后，脂质过氧化水平显著下降。给大鼠喂食乙醇2周、4周和8周后，肝脏中谷胱甘肽过氧化物酶（GPx）、过氧化氢酶和超氧化物歧化酶（SOD）的活性显著升高。有趣的是，给喂食乙醇的大鼠进行锌处理能够使升高的SOD、过氧化氢酶和GPx水平降至正常范围内，然而，单独给予锌并未引起这些抗氧化酶活性的任何显著变化。
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