Kelly Daryl J, Richards Allen L, Temenak Joseph, Strickman Daniel, Dasch Gregory A
Department of Molecular Genetics, Ohio State University, Columbus, OH, USA.
Clin Infect Dis. 2002 Jun 15;34(Suppl 4):S145-69. doi: 10.1086/339908.
Morbidity and mortality caused by rickettsioses have had a major influence on military activities and public health for >2000 years. The threat posed by the rickettsioses is reviewed, focusing on the impact and epidemiology of those that have adversely influenced wartime operations and the current challenges posed by these diseases. With their uneven worldwide distribution, the discovery of drug-refractory strains of Orientia tsutsugamushi, the increased threat of their use in acts of bioterrorism, frequent deployment of troops to regions of endemicity, and exposures due to increased humanitarian missions, these diseases continue to be a threat to military personnel in the field. Effective strategies to reduce the impact of these diseases include development of effective vaccines, enhanced surveillance, and development of new safe, effective, and odorless repellants. The continuation of a proven, highly productive military infectious disease research program is essential for providing solutions to these daunting tasks.
立克次体病所导致的发病和死亡在2000多年来对军事活动和公共卫生产生了重大影响。本文综述了立克次体病所构成的威胁，重点关注那些对战时行动产生不利影响的立克次体病的影响和流行病学，以及这些疾病当前所带来的挑战。鉴于它们在全球分布不均、恙虫病东方体耐药菌株的发现、其被用于生物恐怖主义行为的威胁增加、部队频繁部署到疾病流行地区以及人道主义任务增加导致的暴露情况，这些疾病仍然对战场上的军事人员构成威胁。减少这些疾病影响的有效策略包括研发有效的疫苗、加强监测以及开发新的安全、有效且无味的驱虫剂。持续开展一个经过验证且成果丰硕的军事传染病研究项目对于解决这些艰巨任务至关重要。
