Xie Z, Tan D, Xie J, Qin Q, Tan G, Xu P
Department of Hematology, Xiangya Hospital, Hunan Medical University, Changsha 410008.
Hunan Yi Ke Da Xue Xue Bao. 1999;24(3):245-7.
Cytotoxicity to leukemia cell and enhancement of immunologic functions of jiexinkang (JXK, traditional Chinese medicine) were observed in 34 cases of leukemia in vitro. The results showed that the leukemia cytotoxicity in the group of vincristine combined with JXK was significantly higher than that in vincristine alone. It was also found among all the observed cases that 20 refractory or recurred patients resistant to vincristine showed an obvious intention of the anti-toxicity efficiency when JXK was added. Jiexinkang alone had anti-leukemia cell effect, too. We explored JXK effects on immunologic functions in mice, and found that IFNr and NK activities of normal and experimental model mice were significantly higher than those of control group(P < 0.01). The results indicate that JXK has an effect of anti-leukemia cell and may improve the cell-immunologic functions.
在34例白血病患者中观察了洁心康（JXK，一种中药）对白血病细胞的细胞毒性及免疫功能增强作用。结果显示，长春新碱联合洁心康组的白血病细胞毒性显著高于单用长春新碱组。在所有观察病例中还发现，20例对长春新碱耐药的难治或复发患者加用洁心康后有明显的抗毒增效作用。单用洁心康也有抗白血病细胞作用。我们探讨了洁心康对小鼠免疫功能的影响，发现正常及实验模型小鼠的IFNr和NK活性均显著高于对照组（P<0.01）。结果表明，洁心康具有抗白血病细胞作用，且可能改善细胞免疫功能。
