[知母皂苷E1和E2]

[Timosaponins E1 and E2].

作者信息

Meng Z, Xu S, Meng L

机构信息

Department of Phytochemistry, Shenyang Pharmaceutical Univercity, Shenyang 110015.

出版信息

Yao Xue Xue Bao. 1998 Sep;33(9):693-6.

PMID:12016874

Abstract

By means of silica gel chromatography and HPLC, two compounds were isolated from Anemarrhena asphodeloides Bge.. On the basis of chemical and spectral (MS, 1H, 13CNMR, IR) analyses, their structures were elucidated as (25S)-26-O-beta-D-glucopyranosyl-22-hydroxy-5 beta-furost-3 beta, 15 alpha, 26-triol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (1), and (25S)-26-O-beta-D-glucopyranosyl-22-methoxy-5 beta-furost-3 beta, 15 alpha, 26-triol-3-O-beta-D-glucopyranosyl (1-->2)-beta-D-galactopyranoside (2). They are named as timosaponin E1 (1) and timosaponin E2 (2) respectively. The structure of anemarrhenasaponin-I (A) is briefly discussed. Timosaponins are the main active constituents of Anemarrhena asphodeloides, most of them were shown to can inhibit platelet aggregation.

摘要

通过硅胶柱色谱法和高效液相色谱法，从知母中分离得到两种化合物。基于化学和光谱（质谱、氢谱、碳谱、红外光谱）分析，确定它们的结构分别为(25S)-26-O-β-D-吡喃葡萄糖基-22-羟基-5β-呋甾-3β,15α,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖苷（1）和(25S)-26-O-β-D-吡喃葡萄糖基-22-甲氧基-5β-呋甾-3β,15α,26-三醇-3-O-β-D-吡喃葡萄糖基(1→2)-β-D-吡喃半乳糖苷（2）。它们分别被命名为知母皂苷E1（1）和知母皂苷E2（2）。并简要讨论了知母皂苷-I（A）的结构。知母皂苷是知母的主要活性成分，其中大多数已被证明能够抑制血小板聚集。