[白三烯对小鼠腹腔巨噬细胞白细胞介素6产生的影响]
[Effects of leukotrienes on production of interleukin 6 from mouse peritoneal macrophages].
作者信息
Zhong M, Cheng G, Wang W, Zhou L, Zhu X, Zhang J
机构信息
Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050.
出版信息
Yao Xue Xue Bao. 1998 May;33(5):326-9.
In the present study, effects of leukotrienes on IL-6 production by mouse resident peritoneal macrophages were explored with a bioassay method involving IL-6 dependent murine hybridoma B9 cell line. The results showed that LTB4, LTC4 and LTD4 can enhance the production of IL-6 from cultured peritoneal macrophages of mice. The optimal concentractions for LTB4, LTC4 and LTD4 were found to be 1.45 x 10(-6), 6.9 x 10(-8) and 8.05 x 10(-8) mol.L-1, respectively. The results suggest that peptide leukotrienes might play important role on IL-6 production in the local milieu of inflammation.
在本研究中，采用涉及依赖白细胞介素-6（IL-6）的小鼠杂交瘤B9细胞系的生物测定方法，探讨了白三烯对小鼠腹腔常驻巨噬细胞产生IL-6的影响。结果显示，白三烯B4（LTB4）、白三烯C4（LTC4）和白三烯D4（LTD4）可增强小鼠培养腹腔巨噬细胞中IL-6的产生。发现LTB4、LTC4和LTD4的最佳浓度分别为1.45×10⁻⁶、6.9×10⁻⁸和8.05×10⁻⁸mol·L⁻¹。结果表明，肽白三烯可能在炎症局部环境中对IL-6的产生起重要作用。
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