Grishanin A K, Degtiarev S V, Akif'ev A P
Papanin Institute of Biology of Inland Waters, Russian Academy of Sciences, Borok, Yaroslavl Oblast, 152742 Russia.
Genetika. 2002 Apr;38(4):468-72.
Chromosomal radiosensitivity inferred from the yield of chromosome aberrations (CAs) was for the first time studied in Cyclops (Crustacea, Copepoda) before and after chromatin diminution (CD). A comparison was made for C. kolensis, in which CD denudes somatic embryo cells of the greatest (94%) DNA amount known for multicellular organisms, and C. insignis, which lacks CD. The two species have similar genome sizes, 4.6 and 4.3 pg. respectively. Radiosensitivity of C. kolensis chromosomes proved to be extremely high during prediminution cleavage divisions. This was attributed to membrane damage in granules that contain enzymes (topoisomerases) normally involved in cleavage and ligation of chromosomal DNA during CD.
首次在独眼水蚤（甲壳纲，桡足亚纲）染色质消减（CD）前后，根据染色体畸变（CA）产量推断其染色体辐射敏感性进行了研究。对柯氏独眼水蚤和无饰独眼水蚤进行了比较，在柯氏独眼水蚤中，染色质消减使体细胞胚细胞失去了多细胞生物中已知的最大量（94%）的DNA，而无饰独眼水蚤则没有染色质消减。这两个物种的基因组大小相似，分别为4.6和4.3皮克。事实证明，柯氏独眼水蚤染色体在消减前的卵裂期辐射敏感性极高。这归因于颗粒中的膜损伤，这些颗粒含有通常在染色质消减过程中参与染色体DNA切割和连接的酶（拓扑异构酶）。
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