Kumari A, Kumar U, Agarwal H C
Department of Zoology, University of Delhi, India.
Indian J Exp Biol. 2001 Aug;39(8):811-3.
Imidazole compound KK-42 was tested for its inhibitory effect on Schistocerca gregaria. The compound caused 80% mortality after 19 days of treatment with 100 microg of KK-42/insect. It also caused the production of deformed adults at even lower doses. Ecdysteroid content, when estimated by RIA, declined due to KK-42 treatment in both haemolymph and ovaries of the insect. Reduction in ecdysteroid titer was maximum at 100 microg of KK-42/insect. The value estimated by RIA was 0.34 ng/pL haemolymph as compared to 0.97 ng/microL in case of controls. Similarly,ecdysteroid content of ovaries detected was 0.48 ng/mg in treated ones as compared to 0.61 ng/mg in controls. Histological studies, however, revealed no alteration in the ovarian tissues due to KK-42 treatment.
对咪唑化合物KK - 42进行了其对沙漠蝗抑制作用的测试。用100微克KK - 42/昆虫处理19天后，该化合物导致80%的死亡率。甚至在更低剂量下，它也会导致畸形成虫的产生。通过放射免疫分析（RIA）估计，昆虫血淋巴和卵巢中的蜕皮甾体含量因KK - 42处理而下降。在100微克KK - 42/昆虫时，蜕皮甾体滴度的降低最大。通过RIA估计的值为0.34纳克/微升血淋巴，而对照组为0.97纳克/微升。同样，检测到的处理组卵巢蜕皮甾体含量为0.48纳克/毫克，而对照组为0.61纳克/毫克。然而，组织学研究显示，KK - 42处理未导致卵巢组织发生改变。
