Sakhnini E, Weissmann A, Oren I
Department of Medicine A, Rambam Medical Center and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa.
Am J Med Sci. 2002 May;323(5):269-72. doi: 10.1097/00000441-200205000-00008.
Soft tissue infection caused by Stenotrophomonas maltophilia is uncommon, but nosocomial infections had been reported. We describe herein 2 young female patients, with severe neutropenia, on broad spectrum antimicrobial agents for neutropenic fever, with Hickman-type central venous catheter, who developed mucocutaneous and soft tissue infections with rapidly progressive and devastating course. Cultures from the skin of both patients and from blood of one of them grew S. maltophilia. Both patients died and post mortem examination of the patient with S. maltophilia bacteremia revealed extensive soft tissue necrosis and a vegetation on the mitral valve that grew S. maltophilia. The infection occurred in both patients at the same time and in the same ward. Epidemiological study was done, and surveillance cultures grew the organism from the faucets from the room of 1 patient and also from some of the neighboring rooms in our ward but not from any other ward nor in the water reservoir of the building.
嗜麦芽窄食单胞菌引起的软组织感染并不常见，但已有医院感染的报道。我们在此描述2例年轻女性患者，她们因中性粒细胞减少性发热接受广谱抗菌药物治疗，留置希克曼型中心静脉导管，发生了皮肤黏膜和软组织感染，病程迅速进展且具有破坏性。两名患者皮肤及其中一名患者血液培养均生长出嗜麦芽窄食单胞菌。两名患者均死亡，对患有嗜麦芽窄食单胞菌血症的患者进行尸检发现广泛的软组织坏死以及二尖瓣上生长有嗜麦芽窄食单胞菌的赘生物。两名患者的感染同时发生在同一病房。进行了流行病学研究，监测培养从一名患者病房的水龙头以及我们病房一些相邻房间培养出该菌，但在其他病房及大楼的蓄水池中未培养出。
