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术中射频消融治疗心房颤动的疗效:短期和中期结果

Curative treatment of atrial fibrillation with intraoperative radiofrequency ablation: short-term and midterm results.

作者信息

Mohr Friedrich W, Fabricius Alexander M, Falk Volkmar, Autschbach Rüdiger, Doll Nicolas, Von Oppell Ulrich, Diegeler Anno, Kottkamp Hans, Hindricks Gerd

机构信息

Divisions of Cardiac Surgery and Cardiology, Herzzentrum, University of Leipzig, Leipzig, Germany.

出版信息

J Thorac Cardiovasc Surg. 2002 May;123(5):919-27. doi: 10.1067/mtc.2002.120730.

Abstract

OBJECTIVE

This report describes the early and midterm results after intraoperative radiofrequency ablation of atrial fibrillation for patients with isolated chronic atrial fibrillation or atrial fibrillation in combination with additional valvular and nonvalvular cardiac diseases.

METHODS

From August 1998 to March 2001, a total of 234 patients with chronic atrial fibrillation underwent isolated intraoperative radiofrequency ablation alone (n = 74, 31.6%) or in combination with other cardiac procedures, such as mitral valve reconstruction (n = 57, 24.4%), mitral valve replacement (n = 38, 16.2%), aortic valve replacement (n = 11, 5.1%), coronary artery bypass grafting (n = 8, 5.0%), or a combination of the last with other cardiac procedures (n = 46, 19.7%). In all cases anatomic reentrant circuits confined within the left atrium were eliminated by placing contiguous lesion lines involving the mitral anulus and the orifices of the pulmonary veins through the use of radiofrequency energy application (exposure time, 20 seconds). A median sternotomy was used in 101 cases (43.2%), and video assistance through a right lateral minithoracotomy was used in 133 cases (56.8%).

RESULTS

A total of 188 patients (83.9%) were discharged in sinus rhythm, 17 patients (7.6%) had atrial fibrillation, and 19 patients (8.5%) had atypical flutter. Pacemakers were implanted in 23 patients (9.8%). There were 10 in-hospital deaths (4.2%), and 30-day mortality was 5 patients (2.1%). In 3 cases (1.3%) an atrioesophageal fistula developed, necessitating surgical repair. Six months' follow-up was complete for 122 (61.0%) of 200 patients, with 99 patients still in stable sinus rhythm (81.1%, 95% confidence interval 73.1%-89.9%). Twelve months' follow-up was complete for 80 (90.9%) of 88 patients, with 58 patients still in sinus rhythm (72.5%, 95% confidence interval 61.3%-83.2%).

CONCLUSIONS

Intraoperative radiofrequency ablation is a curative procedure for chronic atrial fibrillation. It is technically less challenging than the maze procedure and can be applied through a minimally invasive approach. Protection of the esophagus seems mandatory to avoid the deleterious complication of a left atrioesophageal fistula, such as was observed in 3 cases.

摘要

目的

本报告描述了孤立性慢性房颤或合并其他瓣膜及非瓣膜性心脏病的房颤患者术中射频消融治疗房颤的早期和中期结果。

方法

1998年8月至2001年3月,共有234例慢性房颤患者接受了单纯术中射频消融(n = 74,31.6%)或与其他心脏手术联合进行,如二尖瓣重建(n = 57,24.4%)、二尖瓣置换(n = 38,16.2%)、主动脉瓣置换(n = 11,5.1%)、冠状动脉旁路移植术(n = 8,5.0%)或最后一种与其他心脏手术联合(n = 46,19.7%)。在所有病例中,通过使用射频能量施加(暴露时间20秒),放置涉及二尖瓣环和肺静脉口的连续病变线,消除局限于左心房内的解剖折返环。101例(43.2%)采用正中胸骨切开术,133例(56.8%)通过右侧小切口胸腔镜辅助手术。

结果

共有188例患者(83.9%)以窦性心律出院,17例患者(7.6%)仍有房颤,19例患者(8.5%)有非典型房扑。23例患者(9.8%)植入了起搏器。住院死亡10例(4.2%),30天死亡率为5例(2.1%)。3例(1.3%)发生了心房食管瘘,需要手术修复。200例患者中有122例(61.0%)完成了6个月的随访,99例患者仍维持稳定的窦性心律(81.1%,95%可信区间73.1%-89.9%)。88例患者中有80例(90.9%)完成了12个月的随访,58例患者仍维持窦性心律(72.5%,95%可信区间61.3%-83.2%)。

结论

术中射频消融是治疗慢性房颤的一种有效方法。它在技术上比迷宫手术难度小,并且可以通过微创方法应用。必须保护食管以避免左心房食管瘘这一有害并发症,如本研究中观察到的3例。

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