Larkin R P
J Comp Physiol Psychol. 1975 Nov;89(9):1100-8. doi: 10.1037/h0077192.
Rats were given bilateral injections of 1-2 mul procaine HCl solution (50 mug/mul) in the region of the ventromedial hypothalamus. Normal-sized meals occurred reliably with a latency of 16-120 sec, indicating that this region has the function of inhibiting onset of eating, not just the function of stopping a meal. Food-rewarded fixed-ratio-of-one (FR 1; continuous reinforcement) lever pressing was elicited by 2-mul but not by 1-mul procaine. The FR 64 pressing appeared to be disrupted during a period of increased activity following procaine injection, although visual observations indicated that the pressing which did occur was normal in topography and was significantly associated in temporal sequence with approaches of the food magazine.
给大鼠双侧注射1 - 2微升盐酸普鲁卡因溶液（50微克/微升）于腹内侧下丘脑区域。正常量的进食可靠地出现，潜伏期为16 - 120秒，这表明该区域具有抑制进食开始的功能，而不仅仅是停止进食的功能。2微升的普鲁卡因能引发食物强化的固定比率为一（FR 1；连续强化）的杠杆按压行为，而1微升则不能。尽管视觉观察表明在注射普鲁卡因后活动增加的一段时间内，FR 64的按压行为似乎受到干扰，但实际发生的按压行为在动作形态上是正常的，并且在时间顺序上与食物盒的靠近显著相关。
