Jevnikar Anthony M, Prange Sean, Zucker Peter, Singh Bhagirath
Department of Microbiology & Immunology, John P. Robarts Research Institute, University of Western Ontario, London, Ontario N6A 5A5, Canada.
Ann N Y Acad Sci. 2002 Apr;958:175-8. doi: 10.1111/j.1749-6632.2002.tb02964.x.
MHC class III genes are important in immune regulation and inflammation, and the gene products of this region are well conserved between species. Their role in diabetes is, however, unknown. We used islets from NOD mice that lacked expression of both MHC class I and class II molecules to test the effect of class III differences on the injury of transplanted NOD islets. Loss of islet MHC class I was highly protective, while deletion of MHC class II had no benefit on islet survival. However the combined absence of both MHC class I and class II expression by NOD islets resulted in a delayed form of injury, when islets were transplanted to NOD mice. As neither MHC class I or II molecules were expressed by donor islet tissue, these results suggest a previously unrecognized and important contribution of MHC class III differences on islet injury following transplantation.
MHC III类基因在免疫调节和炎症中起重要作用，该区域的基因产物在物种间高度保守。然而，它们在糖尿病中的作用尚不清楚。我们使用缺乏MHC I类和II类分子表达的NOD小鼠胰岛来测试III类差异对移植的NOD胰岛损伤的影响。胰岛MHC I类的缺失具有高度保护作用，而MHC II类的缺失对胰岛存活没有益处。然而，当将胰岛移植到NOD小鼠体内时，NOD胰岛同时缺失MHC I类和II类表达会导致一种延迟性损伤形式。由于供体胰岛组织既不表达MHC I类分子也不表达II类分子，这些结果表明MHC III类差异对移植后胰岛损伤有先前未被认识到的重要贡献。
