Parthiban M, Madhavan Radha, Porkodi R, Rajendran C Panchapakesa, Zake L, Sanjeevi C B, Chandrasekaran A N
Department of Rheumatology, Government General Hospital, Madras Medical College, Chennai, India.
Ann N Y Acad Sci. 2002 Apr;958:412-5. doi: 10.1111/j.1749-6632.2002.tb03015.x.
Rheumatoid arthritis (RA) was reported to be associated with class II MHC alleles in different ethnic populations. A similar study was undertaken to determine the association of class II MHC with RA patients of Tamilnadu (Tamil-speaking Hindus), India. Thirty patients with RA and 39 healthy controls were included. Polymorphic second exons of the DRB1, DQA1, and DQB1 genes were amplified and subjected to SSOP typing. No allele was found to be significantly associated with RA. However DRB111 (P = 0.01) and DQB10302 (P = 0.02) were significantly associated with rheumatoid factor-positive RA patients. (All the DRB1*11-positive RA patients had either *04 or *10 allele as their second allele. This study is first of its kind in this population.
据报道，类风湿性关节炎（RA）与不同种族人群的II类主要组织相容性复合体（MHC）等位基因有关。开展了一项类似研究，以确定II类MHC与印度泰米尔纳德邦（说泰米尔语的印度教徒）RA患者之间的关联。纳入了30例RA患者和39例健康对照。对DRB1、DQA1和DQB1基因的多态性第二外显子进行扩增，并进行序列特异性寡核苷酸探针（SSOP）分型。未发现有等位基因与RA显著相关。然而，DRB111（P = 0.01）和DQB10302（P = 0.02）与类风湿因子阳性的RA患者显著相关。（所有DRB111阳性的RA患者的第二个等位基因均为04或*10等位基因。本研究在该人群中尚属首次。
