Vaillant R, Bourgeois-Victor P, Fairand A
Can J Biochem. 1979 Oct;57(10):1245-9.
The development of amylo-1,6-glucosidase activity is studied in fetal rat liver. The activity of control fetuses is high on day 17.5, decreases from day 17.5 to day 19.5, and then rises during the next days. In hypophysectomised fetuses, the increase of the activity is suppressed but not the decrease. Moreover, if the mother is adrenalectomized the decrease and the increase are abolished in hypophysectomised fetuses. Growth hormone administration is quite effective in preventing the decrease in enzyme activity but cortisol treatment does not prevent it. In contrast, cortisol produces a precocious decrease of the activity in intact fetuses. These findings suggest that during fetal life, two hormonal regulation mechanisms are involved in the regulation of amylo-1,6-glucosidase activity: cortisol has a repressive effect on the enzymic activity while growth hormone acts as an inducer.
在胎鼠肝脏中研究了淀粉-1,6-葡萄糖苷酶活性的发育情况。对照胎儿的活性在第17.5天较高，从第17.5天到第19.5天下降，然后在接下来的几天里上升。在垂体切除的胎儿中，活性的增加受到抑制，但下降不受影响。此外，如果母亲进行了肾上腺切除术，垂体切除胎儿中活性的下降和增加都被消除。给予生长激素在预防酶活性下降方面相当有效，但皮质醇治疗不能预防。相反，皮质醇会使完整胎儿的活性过早下降。这些发现表明，在胎儿期，两种激素调节机制参与了淀粉-1,6-葡萄糖苷酶活性的调节：皮质醇对酶活性有抑制作用，而生长激素起诱导作用。
