小鼠微小病毒的小非结构蛋白NS2与运动神经元存活蛋白（Smn蛋白）相互作用并共定位。
Minute virus of mice small nonstructural protein NS2 interacts and colocalizes with the Smn protein.
作者信息
Young Philip J, Jensen Klaus T, Burger Lisa R, Pintel David J, Lorson Christian L
机构信息
Department of Biology, Arizona State University, Tempe, Arizona 85287, USA.
出版信息
J Virol. 2002 Jun;76(12):6364-9. doi: 10.1128/jvi.76.12.6364-6369.2002.
Abstract
The small nonstructural protein NS2 of the minute virus of mice (MVM) is required for efficient viral replication, although its mode of action is unclear. Here we demonstrate that NS2 and survival motor neuron protein (Smn) interact in vitro and in vivo. NS2 and Smn also colocalize in infected nuclei at late times following MVM infection.
摘要
小鼠微小病毒（MVM）的小非结构蛋白NS2是高效病毒复制所必需的，尽管其作用方式尚不清楚。在此，我们证明NS2与生存运动神经元蛋白（Smn）在体外和体内相互作用。在MVM感染后的晚期，NS2和Smn也在受感染的细胞核中共定位。
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