Bruno Ludovica, Schaniel Christoph, Rolink Antonius
Basel Institute for Immunology, Basel, Switzerland.
Cells Tissues Organs. 2002;171(1):38-43. doi: 10.1159/000057690.
In Pax-5 deficient mice, B cell development is blocked at the pre-B I cell stage. In contrast to their wild type counterparts, Pax-5(-/-) pre-B I cells posses an extraordinary developmental plasticity showing hematopoietic stem cell features such as pluripotency and self renewing capacity. Here we review the in vitro and in vivo evidence of this intriguing phenomenon.
在Pax-5基因缺陷的小鼠中，B细胞发育在早前B-I细胞阶段受阻。与野生型对应物相比，Pax-5(-/-)早前B-I细胞具有非凡的发育可塑性，表现出造血干细胞特征，如多能性和自我更新能力。在此，我们综述了这一有趣现象的体外和体内证据。
