Pelosi Giuseppe, Maffini Fausto, Decarli Nicola, Viale Giuseppe
Department of Pathology and Laboratory Medicine, European Institute of Oncology, University of Milan School of Medicine, Via G. Ripamonti 435, 20141 Milan, Italy.
Virchows Arch. 2002 May;440(5):543-6. doi: 10.1007/s00428-001-0580-y. Epub 2002 Jan 22.
Meningothelioid nodules (MNs) are not uncommon lesions of the pulmonary interstitium composed of monomorphic round to spindle cells, likely reactive in nature. Their origin is unsettled, though a derivation from arachnoid-like cells in conditions of perturbed perfusion of the pulmonary tissue has been proposed. Here we confirm the consistent occurrence of intense progesterone-receptor immunoreactivity in MNs fortuitously detected in surgical specimens of lung carcinomas. This finding corroborates the view that these proliferations exhibit arachnoid cell-like differentiation and suggests a role for sex-steroid hormones in the control of their growth.
脑膜上皮样结节（MNs）是肺间质中并不罕见的病变，由单一形态的圆形至梭形细胞组成，本质上可能是反应性的。其起源尚不确定，不过有人提出在肺组织灌注紊乱的情况下，它们起源于蛛网膜样细胞。在此，我们证实在肺癌手术标本中偶然发现的MNs中一致存在强烈的孕激素受体免疫反应性。这一发现支持了这些增生表现出蛛网膜样细胞分化的观点，并提示性甾体激素在其生长控制中发挥作用。
