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[慢波睡眠在睡眠稳态调节中的作用]

[The role of slow wave sleep in the homeostatic regulation of sleep].

作者信息

Puente-Muńoz A I, Pérez-Martínez D A, Villalibre-Valderrey I

机构信息

Servicio de Neurofisiolog a Cl nica; Hospital Cl nico Universitario San Carlos, Madrid, 28040, Espańa.

出版信息

Rev Neurol. 2002;34(3):211-5.

Abstract

OBJECTIVES

The homeostatic regulation of sleep is based on the model devised by Borb ly in 1982. During the sleep waking cycle there is an interaction between the natural tendency to sleep, which increase as the vigil is prolonged (S process) and the circadian variation (C process). In this study, we aimed to find how slow activity (0.5 4.5 Hz) during sleep (SWA), mainly registered in phases 3 and 4, may be an indicator of process S.

PATIENTS AND METHODS

We compared two groups of persons: 10 with chronic sleep deprivation (CSD) (less than 6 hours of sleep/day) as compared with 10 persons who slept more than 6 hours per day, using spectral analysis of their delta activity during sleep.

RESULTS

There was a predominance of delta activity in the group of persons with CSD as compared with the control group.

CONCLUSIONS

An increase in SWA was accompanied by an increased tendency to sleep and may therefore be considered to be a marker for this. This marker allows conditions associated with hypersomnolence due to alteration of process S to be identified.

摘要

目的

睡眠的稳态调节基于博尔贝利1982年提出的模型。在睡眠-觉醒周期中,随着清醒时间延长而增加的自然睡眠倾向(S过程)与昼夜节律变化(C过程)之间存在相互作用。在本研究中,我们旨在探究主要在第3和第4阶段记录到的睡眠期间的慢波活动(0.5 - 4.5赫兹)如何可能是S过程的一个指标。

患者与方法

我们比较了两组人员:10名慢性睡眠剥夺(CSD)患者(每天睡眠少于6小时)和10名每天睡眠超过6小时的人员,通过对他们睡眠期间的δ波活动进行频谱分析。

结果

与对照组相比,CSD组人员的δ波活动占优势。

结论

慢波活动增加伴随着睡眠倾向增加,因此可被视为这方面的一个标志。该标志能够识别由于S过程改变而导致的与嗜睡相关的状况。

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