Vaquero Ruano M, Encinas Martín J L, Ramón Y Cajal S, Cajigal Morales C
Hospital Universitario Clínica Puerta de Hierro, Madrid, España.
Arch Soc Esp Oftalmol. 2002 May;77(5):279-81.
PURPOSE/METHOD: To point out that acanthamoeba keratitis can show therapeutical resistance to dibrome propamidine isethionate (Brolene). We have a late diagnosis case of corneal melting on a bilateral acanthamoeba keratitis.
RESULTS/CONCLUSION: We performed corneal graft in one eye and found histopathological evidence of acanthamoeba. There was relapse in the graft in spite of Brolene treatment and good results when we changed to polyhidroxy methylbigunide (PHMB). In case of therapeutical Brolene resistance, PHMB can be an adequate alternative (Arch Soc Esp Oftalmol 2002; 77: 279-282).
目的/方法：指出棘阿米巴角膜炎可能对异硫氰酸二溴丙脒（Brolene）产生治疗抵抗。我们有一例双侧棘阿米巴角膜炎角膜溶解的晚期诊断病例。
结果/结论：我们对一只眼睛进行了角膜移植，发现了棘阿米巴的组织病理学证据。尽管使用了Brolene治疗，但移植眼仍复发，而改用聚六亚甲基双胍（PHMB）后效果良好。在对Brolene治疗产生抵抗的情况下，PHMB可以是一种合适的替代药物（《西班牙眼科协会档案》2002年；77：279 - 282）。
