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骨科与创伤科病房中乙型肝炎和丙型肝炎的患病率。

Prevalence of hepatitis B and hepatitis C in an orthopaedics and traumatology ward.

作者信息

Villani C, Conte S, Chiozzi F, Iandolo C, Persiani P

机构信息

Clinica Ortopedica e Traumatologica Università degli Studi La Sapienza, Roma.

出版信息

Chir Organi Mov. 2001 Apr-Jun;86(2):167-73.

Abstract

The prevalence of hepatitis C (HCV) was studied in the operative practice of one surgeon for a period of 18 months (1/1/98-31/6/99). Patients were also tested for measurement of liver enzymes, aspartate aminotransferase (AST), alanine aminotransferase (ALT), and hepatitis B virus surface antigen (HbsAg). Out of a total of 911 consecutive patients, 37 (4.06%) were found to have anti-HCV antibodies, using a second-generation screening assay, and 10 (1.09%) to have anti-HBV antibodies. None of the patients (0%) had both anti-HBV antibodies and anti-HCV antibodies. Ten and 21 patients positive for HCV (27% and 56%) were found to have high AST and ALT levels, respectively; 1 and 1 patients positive for HBV (10% and 10%) were found to have high AST and ALT levels, respectively. The authors demonstrated the prevalence of HCV and HBV infection or previous exposure to be higher in the trauma patients (6.6%) who required orthopaedic surgery than in the elective orthopaedic patients (3.3%), and the need for full screening without risk factors. All values for p were calculated using Yates's corrected X2 or Student's t test.

摘要

在一位外科医生18个月(1998年1月1日至1999年6月31日)的手术实践中,对丙型肝炎(HCV)的患病率进行了研究。还对患者进行了肝酶、天冬氨酸转氨酶(AST)、丙氨酸转氨酶(ALT)以及乙肝病毒表面抗原(HbsAg)的检测。在总共911例连续患者中,采用第二代筛查试验发现37例(4.06%)有抗-HCV抗体,10例(1.09%)有抗-HBV抗体。没有患者(0%)同时有抗-HBV抗体和抗-HCV抗体。分别有10例和21例HCV阳性患者(27%和56%)的AST和ALT水平较高;分别有1例HBV阳性患者(10%)的AST和ALT水平较高。作者证明,需要进行骨科手术的创伤患者(6.6%)中HCV和HBV感染或既往接触的患病率高于择期骨科手术患者(3.3%),并且有必要在无危险因素的情况下进行全面筛查。所有p值均使用Yates校正X2或Student t检验计算。

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