Numata Akihiko, Shimoda Kazuya, Gondo Hisashi, Kato Kouji, Aoki Kenichi, Ito Yoshikiyo, Takase Ken, Asano Yoshinobu, Okamura Takashi, Niho Yoshiyuki, Harada Mine
Medicine and Biosystemic Science, Kyushu University Graduate School of Medical Sciences, 3-3-3 Maidashi, Higashi-ku, Fukuoka city, Fukuoka 812-8582, Japan.
Br J Haematol. 2002 Jun;117(3):613-6. doi: 10.1046/j.1365-2141.2002.03517.x.
A 17-year-old Japanese woman with Ewing's sarcoma was initially treated with conventional chemotherapy and local irradiation, and then with high-dose chemotherapy supported by autologous peripheral blood stem cell transplantation. Four years later she was diagnosed with chronic myelogenous leukaemia (CML). The BCR/ABL fusion gene was detected in both peripheral blood and bone marrow cells by reverse transcription-polymerase chain reaction, but not in the harvest product of peripheral blood stem cells which were infused at the time of transplantation. This case adds to the accumulating evidence of therapy-related CML developing after high-dose chemotherapy and autologous stem cell transplantation.
一名患有尤因肉瘤的17岁日本女性最初接受了传统化疗和局部放疗，随后接受了自体外周血干细胞移植支持的大剂量化疗。四年后，她被诊断出患有慢性粒细胞白血病（CML）。通过逆转录聚合酶链反应在外周血和骨髓细胞中检测到了BCR/ABL融合基因，但在移植时输注的外周血干细胞收获产物中未检测到。该病例进一步证明了大剂量化疗和自体干细胞移植后发生治疗相关CML的证据不断积累。
