Chennaoui M, Gomez Merino D, Lesage J, Drogou C, Guezennec C Y
Département de Physiologie, IMASSA-CERMA, Brétigny-sur-Orge, France.
Acta Physiol Scand. 2002 Jun;175(2):113-21. doi: 10.1046/j.1365-201X.2002.00971.x.
The influence of the two distinct training programmes, moderate (M) and intensive (I), on hypothalamo-pituitary-adrenal (HPA) axis was investigated, in rats. Changes in plasma concentrations of adrenocorticotropin hormone (ACTH) and corticosterone were followed in response to (i) a 60-min acute running session performed on 2nd, 4th and 6th of the seven training weeks (ii) an acute restraint stress of 40 min applied after the final training programme. After 2nd, 4th and 6th week of the two training programmes, a 60-min running resulted in an enhanced secretion of ACTH and corticosterone, compared with both the baseline values (i.e. before running) and to the sedentary (S) group. However, on 4th and 6th weeks compared with 2nd week, ACTH and corticosterone remained elevated in intensive group when they are significantly reduced in moderate group. We could suggest that a moderate training resulted in an adapted hormonal response whereas a deadapted process occurred for the intensive programme. The day after the last training session, basal ACTH, corticosterone and corticosteroid-binding globulin (CBG) capacity were not affected by training. Hypothalamic corticotropin-releasing factor tissue-content (CRF) was increased significantly in the two trained groups. When compared with the sedentary group, the body weight of the rats in the two trained groups was significantly decreased with a total adrenal mass increasing but only in intensive group. The surimposed restraint stress resulted in significant increases in plasma ACTH and corticosterone both in trained and in sedentary animals. This result suggests that the adapted HPA axis response induced by both a moderate and intensive training do not prevent against the effects of a novel stress such as restraint stress.
研究了两种不同训练方案，即适度（M）训练和强化（I）训练，对大鼠下丘脑-垂体-肾上腺（HPA）轴的影响。在七个训练周的第2、4和6天，进行60分钟的急性跑步训练（i），并在最终训练方案后施加40分钟的急性束缚应激，随后监测促肾上腺皮质激素（ACTH）和皮质酮的血浆浓度变化。在两种训练方案的第2、4和6周后，与基线值（即跑步前）和久坐（S）组相比，60分钟的跑步导致ACTH和皮质酮分泌增加。然而，在第4周和第6周，与第2周相比，强化组的ACTH和皮质酮仍保持升高，而适度组则显著降低。我们可以认为，适度训练导致了适应性的激素反应，而强化训练方案则出现了失适应过程。最后一次训练后的第二天，基础ACTH、皮质酮和皮质类固醇结合球蛋白（CBG）能力不受训练影响。两个训练组的下丘脑促肾上腺皮质激素释放因子组织含量（CRF）均显著增加。与久坐组相比，两个训练组大鼠的体重显著下降，总肾上腺质量增加，但仅在强化组。叠加的束缚应激导致训练组和久坐组动物的血浆ACTH和皮质酮均显著增加。这一结果表明，适度和强化训练诱导的适应性HPA轴反应并不能预防诸如束缚应激等新应激的影响。
