具有两个影响PCR-SSP分型的沉默突变的新DR12等位基因序列。
Sequence of a new DR12 allele with two silent mutations that affect PCR-SSP typing.
作者信息
Zanone R, Bettens F, Tiercy J-M
机构信息
National Reference Laboratory for Histocompatibility, Transplantation Immunology Unit, University Hospital, Geneva, Switzerland.
出版信息
Tissue Antigens. 2002 Feb;59(2):165-7. doi: 10.1034/j.1399-0039.2002.590221.x.
A new HLA-DR12 allele has been identified in a European Caucasoid bone marrow donor. The DRB112012 allele differs from DRB112011 by two silent substitutions at codons 72 and 78, two polymorphic positions used for DNA subtyping of the DR12 serotype. The co-occurence of the two nucleotide changes is unique to the DR12 group and results in a new PCR-SSP typing pattern. The complete HLA type of the donor is A24, A68; B55, B61; Cw01, Cw0304; DRB112012, DRB11402; DRB30101, DRB30202; DQB10301. HLA-DRB112012 is a rare allele as it occurs in < 0.2% of DR12 donors.
在一名欧洲白种人骨髓供者中发现了一个新的HLA - DR12等位基因。DRB112012等位基因与DRB112011的区别在于第72和78密码子处有两个沉默替换，这是用于DR12血清型DNA分型的两个多态性位点。这两个核苷酸变化的同时出现是DR12组所特有的，并导致了一种新的PCR - SSP分型模式。该供者的完整HLA类型为A24, A68; B55, B61; Cw01, Cw0304; DRB112012, DRB11402; DRB30101, DRB30202; DQB10301。HLA - DRB112012是一个罕见等位基因，因为它在<0.2%的DR12供者中出现。
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