Gayral M N, Millet D, Mandelbaum J, Serfaty D, Netter A
Ann Endocrinol (Paris). 1975 Jul-Aug;36(4):211-2.
Ten typical cases of male eunuchoidism (two with anosmia) are reported. After administration of clomifene citrate to five patients, there is no change in blood levels of gonadotrophins in four cases; in the fifth, a small and transitory increase of LH is noted. The intravenous injection of LHRH (100 mug) to five patients induces an increase of serum LH in all cases and serum FSH in three cases. The initial site of the dysfunction is possibly hypothalamic with secondary gonadotrophic pituitary insufficiency. Among six patients anxious for paternity, prolonged treatment (for 36 to 98 weeks), with HCG (250-1 000 I.U. daily) +HMG (65-120 I.U. FSH daily) results in appearance of spermatozoa in the seminal fluid in five cases and a pregnancy was obtained in four cases. Comments are done upon methods of treatment.
报告了10例典型男性类无睾症病例（其中2例伴有嗅觉缺失）。对5例患者给予枸橼酸氯米芬后，4例患者的促性腺激素血水平无变化；第5例患者的促黄体生成素（LH）有小幅短暂升高。对5例患者静脉注射促性腺激素释放激素（LHRH，100微克）后，所有病例的血清LH均升高，3例患者的血清促卵泡生成素（FSH）升高。功能障碍的初始部位可能是下丘脑，继发垂体促性腺激素功能不全。在6例渴望生育的患者中，采用人绒毛膜促性腺激素（HCG，每日250 - 1000国际单位）+人绝经期促性腺激素（HMG，每日65 - 120国际单位FSH）进行长期治疗（36至98周），5例患者精液中出现精子，4例患者成功受孕。对治疗方法进行了讨论。
