Mérat S, Rousseau J M, Lerecouvreux M, Vincenti-Rouquette I, Brinquin L
Département d'anesthésie-réanimation, hôpital d'instruction des armées du Val de Grâce, 74, boulevard de Port Royal, 75005, Paris, France.
Ann Fr Anesth Reanim. 2002 Apr;21(4):295-8. doi: 10.1016/s0750-7658(02)00590-7.
We report the case of a 51-year-old man with an allergy to amoxicillin/acid clavulanique who presented with Streptococcus pneumoniae meningitis. Initial treatment consisted of an association of antibiotics including ceftriaxone. Six days after treatment was initiated the patient developed skin reaction and the diagnosis of allergy to ceftriaxone was established by the dosage of specific IgE. Typically Streptococcus pneumoniae meningitis is treated with vancomycin and a third-generation cephalosporin. This association had to be modified because cross allergy to cephalosporins could have developed in this patient who had previously reacted to penicillins.
我们报告了一例51岁对阿莫西林/克拉维酸过敏的男性患者，其患有肺炎链球菌脑膜炎。初始治疗包括使用包括头孢曲松在内的抗生素联合治疗。治疗开始六天后，患者出现皮肤反应，通过特异性IgE检测确诊对头孢曲松过敏。通常，肺炎链球菌脑膜炎用万古霉素和第三代头孢菌素治疗。由于该患者先前对青霉素有反应，可能已发生对头孢菌素的交叉过敏，因此必须调整这种联合用药方案。
